Once-Daily, LoreevXR™ (lorazepam) Extended Release Capsules. 1mg / 1.5mg / 2mg / 3mg

Once-Daily pharmacokinetic profile12

LOREEV XR 3 mg Once-Daily vs lorazepam immediate-release (IR) tablets 1 mg q8h12

Study design (N=48): Randomized, open-label, 2-way cross-over, 2-period, 2-sequence, 2-treatment, relative bioavailability study at steady state, with a 10-day washout period. Pharmacokinetic profile draws on day 8. Steady state was achieved by day 5.2

Steady-state 24-hour pharmacokinetic profile12

  • Median Tmax of 9 hours
  • Minimal fluctuations throughout the day
  • Bioequivalent to lorazepam tablets dosed q8h

Once-Daily dosing1

  • 1 mg, 1.5 mg, 2 mg, 3 mg extended-release capsules
  • Option to sprinkle dose
  • Dose in the mornings, with or without food

Metabolism of LOREEV XR13

  • Lorazepam is not metabolized via the Cytochrome P450 isoenzyme pathway
  • Lorazepam is metabolized via glucuronidation
    • No active metabolites

LOREEV XR Savings Program

Copay card. Pay as little as $20 per month
Not actual copay card.

Help eligible patients save on Once-Daily lorazepam with the LOREEV XR copay card1

Download copay card
*Applies to commercially insured patients. Benefits are available for cash-paying and not covered patients.


  1. LOREEV XR. Prescribing information. Almatica Pharma LLC; 2021.
  2. Data on file. Almatica Pharma LLC; 2020.
  3. Altamura AC, Moliterno D, Paletta S, Maffini M, Mauri MC, Bareggi S. Understanding the pharmacokinetics of anxiolytic drugs. Expert Opin Drug Metab Toxicol. 2013;9(4):423-440. doi:10.1517/17425255.2013.759209