Not an actual patient.

Help patients gain control of their day.
Treat their anxiety with LOREEV XR®, a once-daily extended-release capsule.1

Convenient once-daily dosing

Administer once daily in the morning, with or without food1

Sprinkle dose1

  • Patients have the option to open the capsule and sprinkle the entire contents over a tablespoon of applesauce, followed by drinking water
  • Do not crush or chew LOREEV XR

To switch patients from lorazepam IR to LOREEV XR:

  • Discontinue lorazepam immediate-release (IR) tablets and administer the first dose of LOREEV XR the next morning1
  • Once-daily dosage of LOREEV XR is equal to the total daily dose of lorazepam IR tablets1

Formulated to deliver a smooth PK profile throughout the day for patients124

Steady-state, 24-hour PK profile2

  • Median Tmax of 9 hours at steady state2
  • Minimal fluctuations throughout the day2
  • Bioequivalent to lorazepam IR tablets dosed 3 times daily at steady state4

LOREEV XR 3 mg once daily vs lorazepam IR tablets 1 mg q8h14

Chart that shows the benefits of the LoreevXR formulation

Study design (N=48):

Randomized, open-label, 2-way crossover, 2-period, 2-sequence, 2-treatment, relative bioavailability study at steady state, with a 10-day washout period. PK profile draws on day 8. Steady state was achieved by day 5.14

Two-bead extended-release delivery system

Diagram showing capsule containing beads
Visual representation. Not actual pill or bead size.

LOREEV XR combines 2 types of extended-release beads to provide a smooth 24-hour profile2

  • Extended-release beads begin to slowly release after ingestion; delayed extended-release beads begin to release several hours after ingestion2
  • The combination of different bead-release profiles delivers:
    • Slow plasma level rise to Cmax (Tmax 9 hours)2
    • Minimal plasma level fluctuation over 24 hours2

Lorazepam is not metabolized via the cytochrome (CYP450) isoenzyme pathway135

Approximately 70% to 80% of all drugs in clinical use are metabolized through the CYP450 pathway.5

Lorazepam is metabolized via glucuronidation13

  • Has no active metabolites
  • Is rapidly conjugated into the inactive lorazepam glucuronide

Help your patients manage their medication costs

Copay Card
Not actual copay card.

With the LOREEV Patient Savings Program, eligible insured patients pay as little as $20/month for LOREEV XR*

Download information about the Patient Savings Program

* Applies to commercially insured patients. Individual costs may vary. Program eligibility and restrictions apply.

Request a rep
Request a rep


  1. LOREEV XR. Prescribing information. Almatica Pharma LLC; 2023.
  2. Saltel DA, Vachon M. Edgemont Pharmaceuticals LLC. Sustained release formulations of lorazepam. US patent 8,999,393 B1. April 7, 2015.
  3. Altamura AC, Moliterno D, Paletta S, Maffini M, Mauri MC, Bareggi S. Understanding the pharmacokinetics of anxiolytic drugs. Expert Opin Drug Metab Toxicol. 2013;9(4):423-440.
  4. Data on file. Almatica Pharma LLC; 2020.
  5. Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013;138(1):103-141.